Frequently Used Excipients in Ophthalmic Preparation


A list of excipients used in ophthalmic preparation are given below-

Vehicles

Water for injections, Boric acid vehicle, Special boric acid vehicle, Isotonic phosphate vehicle etc.

Buffering Agents

Boric acid, Sodium acid phosphate, Disodium Hydrogen Phosphate Dodecahydrate, Sodium citrate, Potassium chloride and Sodium carbonate etc.

Tonicity Agents

Sodium chloride, Potassium chloride, Mannitol etc.

Preservative

Phenylmercuric nitrate, Benzalkonium chloride, Chlorhexidine acetate, Hydroxybenzoates, Chlorocresol, Chlorbutol, Thiomersal, Sodium perborate etc.

Reducing Agents

Sodium metabisulphite, Sodium thiosulphate etc.

Anti-oxidants

Ascorbic acid, Butylated Hydroxyanisole, Butylated Hydroxytoluene, Sodium thiosulphate pentahydrate etc.

Sequestering Agents

Disodium edetate, Sodium citrate etc.

Dissolution Enhancer

Povidone, Macrogol 15 hydroxystearate, Cyclodextrin etc.

Viscosity Enhancer

Polyvinyl alcohol, Methyl cellulose, Bentonite etc.

Suspending Agents

Bentonite, Carbomer, Methyl cellulose etc.

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