Antioxidant and Its Impact on Pharmaceutical Products


Antioxidant
Antioxidant is a substance that inhibits oxidation, especially one used to counteract the deterioration of stored food products.

Oxidation is a chemical reaction that can produce free radicals, leading to chain reactions that may damage cells or degrade the productsproducts. Antioxidants such as thiols or ascorbic acid (vitamin C) terminate these chain reactions.

Classification
Antioxidants are classified into two broad divisions, depending on whether they are soluble in water (hydrophilic) or in lipids (lipophilic). In general, water-soluble antioxidants react with oxidants in the cell cytosol and the blood plasma, while lipid-soluble antioxidants protect cell membranes from lipid peroxidation.

Examples
  • Vitamin C (Ascorbic acid)
  • Vitamin E (Alpha tocopherols)
  • Sodium Metabisulfite
  • Sodium Thiosulfate Pentahydrate
  • Butylated hydroxyanisole
  • Butylated hydroxytoluene

    Antioxidant Impact on Pharmaceutical Products
    The addition of antioxidant to pharmaceutical products is essential for avoiding alteration and degradation by oxidation during storage. Its presence within IIG limit does not impair the bio-availability, the therapeutic efficacy or safety of the preparation, and does not interfere with analysis and tests prescribed for determining compliance with the official pharmacopeias standards.

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